Areas of research that are considered
in-scope for an ADVANCE research grant, with the condition of interest being osteoarthritis (OA) and chronic pain associated with OA, will include studies that aim to advance the understanding of the following.
Evaluation of unmet medical needs in pain management associated with OA
1 as follows:
Benefit-risk assessment and patient preference in the choice of pain medication for patients with comorbid conditions (e.g., cardiovascular disease or history of substance abuse)
How risks associated with long-term use of analgesics are assessed currently
Treatment of chronic pain in special populations (e.g., postsurgical, elderly)
Evaluation of multi-disciplinary approaches to management of OA (e.g., physical therapy, cognitive behavioral therapy [CBT]) and their combination with pharmacological treatment
Understand and predict response to treatment,
6,7 disease state, and course of OA (normal and rapid trajectories)
Approaches to improving adherence to therapy or therapeutic regimes for pain associated with OA
Use of patient characteristics such as biomarkers or other objective evaluations (e.g., quantitative sensory testing [QST], imaging modalities) in the assessment and management of OA to better understand disease course
Evaluation of improved function
How changes of physical function are assessed in clinical practice in patients with OA, and how current physical function assessment could be improved
How individual goal setting can contribute to treatment outcome (including pain and function)
What impact the improved physical function has on the patients’ quality of life
Areas that are considered
out of scope and will NOT be considered for an ADVANCE research grant include:
Studies not involving OA
Studies involving pregnant or lactating females and/or participants
18 years of age
Any drug requests
Requests for funding from countries that currently have restrictions on trade with the United States
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